[{"data":1,"prerenderedAt":1175},["Reactive",2],{"endpoints.events.index/events/asgct-annual-meeting-2026-in-boston/":3},[4,39,82,118,162,189,230,275,318,365,402,438,473,507,535,567,592,624,657,707,733,761,789,823,854,887,921,972,1018,1050,1082,1113,1145],{"title":5,"slug":8,"description":10,"start":11,"end":12,"place":13,"subtitle":15,"links":16,"claim":21,"content":22},{"de":6,"en":7},"","ASGCT Annual Meeting 2026 in Boston",{"de":6,"en":9},"asgct-annual-meeting-2026-in-boston",{"de":7,"en":7},"2026-05-11","2026-05-15",{"de":6,"en":14},"Boston, MA",{"de":6,"en":6},[17],{"title":18,"target":20},{"de":6,"en":19},"ASGCT Annual Meeting 2026","https://annualmeeting.asgct.org/",{"de":6,"en":6},[23],{"headline":24,"subline":25,"description":26,"text":27,"images":29,"files":38},{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":28},"\u003Cp>\u003Cstrong>We are excited to attend the ASGCT Annual Meeting 2026 in Boston\u003C/strong> - one of the leading global events dedicated to advancing cell and gene therapy research and clinical translation.\u003C/p>\u003Cp>Join us to discuss how high-quality plasmid and Minicircle DNA can support your gene and cell therapy programs from early-stage research to GMP-compliant manufacturing.\u003C/p>\u003Ch3>Visit us at booth #1064\u003C/h3>\u003Cp>Stop by our booth to connect with our team and explore how optimized plasmid and Minicircle DNA solutions can:\u003C/p>\u003Cul>\u003Cli>\u003Cp>Enable efficient AAV vector production\u003C/p>\u003C/li>\u003Cli>\u003Cp>Support virus-free cell engineering strategies\u003C/p>\u003C/li>\u003Cli>\u003Cp>Improve safety profiles in T cell applications\u003C/p>\u003C/li>\u003Cli>\u003Cp>Facilitate scalable GMP manufacturing\u003C/p>\u003C/li>\u003C/ul>\u003Chr>\u003Ch3>Poster Presentations\u003C/h3>\u003Cp>In addition to meeting us at our booth, we are proud to present the following scientific contributions:\u003C/p>\u003Cp>\u003Cstrong>Abstract title: Minimal DNA constructs for AAV vector productions with exceedingly high genomic purity\u003C/strong>\u003C/p>\u003Cul>\u003Cli>\u003Cp>Abstract ID: 2155\u003C/p>\u003C/li>\u003Cli>\u003Cp>Presentation Day: May 13, 2026\u003C/p>\u003C/li>\u003C/ul>\u003Cp>\u003Cstrong>Abstract title: Minicircle DNA transfection by SM-102 lipid nanoparticles into HEK cells led to prolonged transient expression compared to plasmids or mRNA\u003C/strong>\u003C/p>\u003Cul>\u003Cli>\u003Cp>Abstract ID: 3097\u003C/p>\u003C/li>\u003Cli>\u003Cp>Presentation Day: May 14, 2026\u003C/p>\u003C/li>\u003C/ul>\u003Cp>\u003Cstrong>Abstract title: Characterization of ready-to-use Lipid Nanoparticle Delivery Kits for efficient intracellular delivery of nucleic acids\u003C/strong>\u003C/p>\u003Cul>\u003Cli>\u003Cp>Abstract ID: 3083\u003C/p>\u003C/li>\u003Cli>\u003Cp>Presentation Day: May 14, 2026\u003C/p>\u003C/li>\u003C/ul>\u003Chr>\u003Ch3>Let’s schedule a meeting in Boston\u003C/h3>\u003Cp>Would you like to arrange a dedicated meeting during ASGCT?\u003C/p>\u003Cp>Get in touch with our team in advance to discuss your current projects, technical challenges, and development strategy.\u003C/p>\u003Cp>You can reach us at \u003Ca target=\"_blank\" href=\"mailto:contact@plasmidfactory.com\" tt-mode=\"url\">\u003Cstrong>contact@plasmidfactory.com\u003C/strong>\u003C/a> to schedule a meeting.\u003C/p>",[30,34],{"url":31,"alt":32},"https://api.plasmidfactory.com/storage/276/responsive-images/BILD-ASGCT-Boston26-City___webp_W___WIDTH____H.webp",{"de":6,"en":33},"Boston City",{"url":35,"alt":36},"https://api.plasmidfactory.com/storage/277/responsive-images/BILD-ASGCT-Boston26-Logo___webp_W___WIDTH____H.webp",{"de":6,"en":37},"ASGCT Logo",[],{"title":40,"slug":42,"description":44,"start":47,"end":47,"place":48,"subtitle":50,"links":52,"claim":57,"content":58},{"de":6,"en":41},"Webinar - Why DNA Quality Matters – from Research to GMP",{"de":6,"en":43},"why-dna-quality-matters-from-research-to-gmp",{"de":45,"en":46},"Webinar - Why DNA Quality Matters – and How the Right Partner Supports Your Program from Research to GMP","Webinar -Why DNA Quality Matters – and How the Right Partner Supports Your Program from Research to GMP","2026-03-26",{"de":6,"en":49},"17:00 CET / 16:00 GMT / 11:00 EST / 08:00 PST",{"de":6,"en":51},"Speaker Dr. Martin Schleef - Founder & Senior Advisor, PlasmidFactory GmbH",[53],{"title":54,"target":56},{"de":6,"en":55},"Watch Webinar Recording","https://www.youtube.com/watch?v=guWjMkPmTVg",{"de":6,"en":6},[59],{"headline":60,"subline":61,"description":62,"text":63,"images":65,"files":73},{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":64},"\u003Cp>\u003Ca target=\"_self\" href=\"https://www.youtube.com/watch?v=guWjMkPmTVg\" tt-mode=\"url\">WEBINAR RECORDING\u003C/a>\u003C/p>\u003Cp>\u003C/p>\u003Cp>Plasmid DNA and Minicircle DNA are critical starting materials for advanced therapeutic programs across e.g. cell and gene therapy and vaccine development, including applications such as CAR-T and other gene-modified cell therapies, virus-free gene transfer approaches, mRNA-based applications, and AAV vector manufacturing. Despite their central role, DNA is often considered a basic input early on until development slows down due to quality, scalability, or regulatory challenges.\u003C/p>\u003Cp>In this webinar, Dr. Martin Schleef, the founder of PlasmidFactory shares insights from more than 25 years of supporting customer programs with plasmid and Minicircle DNA, from early research through GMP-compliant clinical supply. The focus is on how the right DNA strategy and the right partner can reduce risk and actively support program success.\u003C/p>\u003Cp>Typical challenges addressed include insufficient transfection efficiency and unstable expression, unwanted bacterial sequences affecting safety and consistency, limitations of plasmid DNA in virus-free gene modification, and quality issues such as retro-packaging in AAV production or instability of ITR and poly(A) sequences. These challenges directly impact yields, reproducibility, regulatory acceptance, and overall timelines. Minicircle DNA and related technologies address these issues by enabling cleaner vectors, higher functional performance, improved safety profiles, and better suitability for clinical applications.\u003C/p>\u003Cp>The webinar presents PlasmidFactory’s end-to-end approach, combining Minicircle DNA with proprietary technologies such as ITRRESCUE®, ITRPROTECT®, and POLYARESCUE®, supported by an integrated GMP manufacturing system. Through close scientific collaboration and long-term partnership, PlasmidFactory helps customers make DNA supply the most stable and lowest-risk element of their development programs.\u003C/p>\u003Cp>\u003Cu>Learning Objectives\u003C/u>\u003C/p>\u003Cp>After this webinar, participants will be able to:\u003C/p>\u003Cul>\u003Cli>\u003Cp>• Understand how DNA quality directly affects performance, safety, and scalability\u003C/p>\u003C/li>\u003Cli>\u003Cp>• Recognize how Minicircle-based solutions address common development challenges\u003C/p>\u003C/li>\u003Cli>\u003Cp>• Evaluate how an end-to-end DNA partner can support programs from research to GMP\u003C/p>\u003C/li>\u003C/ul>",[66,69],{"url":67,"alt":68},"https://api.plasmidfactory.com/storage/248/responsive-images/martin-schleef___webp_W___WIDTH____H.webp",{"de":6,"en":51},{"url":70,"alt":71},"https://api.plasmidfactory.com/storage/268/responsive-images/DNA-Quality-Visual-web___webp_W___WIDTH____H.webp",{"de":6,"en":72},"DNA Isoforms",[74,78],{"file":75,"title":76},"https://api.plasmidfactory.com/storage/270/Webinar-2026-03-25-MartinSchleef-DNA-Quality-digital.pdf",{"de":6,"en":77},"Webinar Flyer",{"file":79,"title":80},"https://api.plasmidfactory.com/storage/274/PlasmidFactory-Webinar_Why-DNA-Quality-Matters-From-Research-To-GMP_Dr.-Martin-Schleef.pdf",{"de":6,"en":81},"Webinar Slides",{"title":83,"slug":85,"description":87,"start":89,"end":90,"place":91,"subtitle":93,"links":94,"claim":99,"content":100},{"de":6,"en":84},"Advanced Therapies 2026 in London",{"de":6,"en":86},"advanced-therapies-2026-in-london",{"de":88,"en":88},"Advanced Therapies 2026 - London","2026-03-17","2026-03-18",{"de":6,"en":92},"London, UK",{"de":6,"en":6},[95],{"title":96,"target":98},{"de":6,"en":97},"Advanced Therapies 2026","https://www.terrapinn.com/congress/advanced-therapies/index.stm",{"de":6,"en":6},[101],{"headline":102,"subline":104,"description":105,"text":106,"images":108,"files":117},{"de":6,"en":103},"Visit us at Booth #275",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":107},"\u003Cp>We’ll be attending the Advanced Therapies Congress in London and would love to meet and connect!\u003C/p>\u003Cp>Let’s talk about how our high-quality plasmid and Minicircle DNA can support your gene and cell therapy projects from early-stage research to GMP manufacturing.\u003C/p>\u003Cp>\u003Cstrong>Poster Presentation\u003C/strong>\u003C/p>\u003Cp>\u003Cem>“Safer, Scalable T Cell Engineering”\u003C/em>\u003C/p>\u003Cp>Visit our poster to learn more about how optimized DNA solutions can enhance safety, scalability and efficiency in T cell engineering workflows.\u003C/p>\u003Cp>\u003C/p>\u003Cp>\u003Cstrong>Our team members on site:\u003C/strong>\u003C/p>\u003Cp>\u003Cstrong>Dr. Marcello Stein\u003C/strong> – Senior Director Strategic Marketing\u003Cbr>\u003Ca target=\"_blank\" href=\"mailto:marcello.stein@plasmidfactory.com\" tt-mode=\"url\">marcello.stein@plasmidfactory.com\u003C/a>\u003C/p>\u003Cp>\u003Cstrong>Adam Thakore\u003C/strong> – Associate Director Business Development\u003Cbr>\u003Ca target=\"_blank\" href=\"mailto:adam.thakore@plasmidfactory.com\" tt-mode=\"url\">adam.thakore@plasmidfactory.com\u003C/a>\u003C/p>\u003Cp>They’ll be happy to discuss your current projects, challenges, and how we can support your development strategy.\u003C/p>\u003Cp>Would you like to schedule a meeting in London?\u003Cbr>Get in touch directly with Marcello or Adam, or contact us at \u003Ca target=\"_blank\" href=\"mailto:contact@yourcompany.com\" tt-mode=\"url\">contact@yourcompany.com\u003C/a> to arrange a time.\u003C/p>\u003Cp>The Advanced Therapies Congress brings together leaders from biotech, pharma, academia, and investment to accelerate the development and commercialization of cell and gene therapies.\u003Cbr>Learn more about the event on the official Advanced Therapies Congress website.\u003C/p>",[109,113],{"url":110,"alt":111},"https://api.plasmidfactory.com/storage/266/responsive-images/BILD-AdvTherap-Logo___webp_W___WIDTH____H.webp",{"de":6,"en":112},"Advanced Therapies Logo",{"url":114,"alt":115},"https://api.plasmidfactory.com/storage/267/responsive-images/BILD-AdvTherap-London___webp_W___WIDTH____H.webp",{"de":6,"en":116},"Skyline London",[],{"title":119,"slug":121,"description":123,"start":124,"end":124,"place":125,"subtitle":127,"links":128,"claim":133,"content":134},{"de":6,"en":120},"Webinar - Virus-Free Gene Modification with Minicircle DNA for Advanced Cell Therapies",{"de":6,"en":122},"webinar-virus-free-gene-modification-with-minicircle-dna-for-advanced-cell-therapies",{"de":120,"en":120},"2025-12-10",{"de":6,"en":126},"17:00 CET / 16:00 GMT / 11:00 ET / 08:00 PT",{"de":6,"en":6},[129],{"title":130,"target":132},{"de":6,"en":131},"Webinar Recording","https://youtu.be/_cfMU3maEwI",{"de":6,"en":6},[135],{"headline":136,"subline":138,"description":139,"text":140,"images":142,"files":150},{"de":6,"en":137},"Speaker Dr. Dirk Winnemöller - Chief Executive Officer, PlasmidFactory GmbH",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":141},"\u003Cp>\u003Ca target=\"_blank\" href=\"https://youtu.be/_cfMU3maEwI\" tt-mode=\"url\">Watch Webinar Recording\u003C/a>\u003C/p>\u003Cp>\u003C/p>\u003Cp>Viral vectors remain the current standard for generating gene-modified cells, yet their use is often limited by complex manufacturing, cost, and safety considerations. As the field progresses toward scalable and regulatory-ready solutions, non-viral gene delivery has become an increasingly attractive alternative, \u003Cem>in vivo\u003C/em> and \u003Cem>ex vivo\u003C/em>.\u003C/p>\u003Cp>PlasmidFactory’s Minicircle DNA technology provides a high-quality, bacterial-backbone-free vector for virus-free engineering of e.g. immune cells, stem cells and beyond. Published studies have demonstrated that minicircle-based constructs, when used in systems such as Sleeping Beauty transposition, enable efficient and stable gene transfer with reduced DNA toxicity, lower insertional risk and lower costs compared to lentiviral approaches.\u003C/p>\u003Cp> \u003C/p>\u003Cp>\u003Cu>This webinar will present:\u003C/u>\u003C/p>\u003Cp>The scientific principles and design advantages of minicircle DNA for cell therapy applications.\u003C/p>\u003Cp>Insights from published preclinical and clinical studies employing minicircle-based cell engineering (e.g. CAR Ts, TCR Ts, CAR NKs, HSPCs).\u003C/p>\u003Cp>Perspectives on scalability, GMP readiness, and the potential of minicircles in emerging in vivo gene-delivery approaches using LNP/PNP or other virus-free systems.\u003C/p>\u003Cp> \u003C/p>\u003Cp>Join us to learn how Minicircle DNA can support safer, flexible, and efficient manufacturing of the next generation of gene-modified cell therapies.\u003C/p>",[143,146],{"url":144,"alt":145},"https://api.plasmidfactory.com/storage/212/responsive-images/BILD-Dirk___webp_W___WIDTH____H.webp",{"de":6,"en":137},{"url":147,"alt":148},"https://api.plasmidfactory.com/storage/235/responsive-images/GMCT-Visuals1-klein-web___webp_W___WIDTH____H.webp",{"de":6,"en":149},"CAR-T-cell Production",[151,154,158],{"file":152,"title":153},"https://api.plasmidfactory.com/storage/236/Webinar-2025-12-10-DirkWinnemöller-VirusFreeGeneModifiedCells-final-digital.pdf",{"de":6,"en":77},{"file":155,"title":156},"https://api.plasmidfactory.com/storage/246/Flyer_CAR-T_MC.pdf",{"de":6,"en":157},"CAR-T Solutions - Flyer",{"file":159,"title":160},"https://api.plasmidfactory.com/storage/247/Webinar_GMCT_final.pdf",{"de":6,"en":161},"Webinar Slide Deck",{"title":163,"slug":165,"description":167,"start":168,"end":169,"place":170,"subtitle":172,"links":173,"claim":178,"content":179},{"de":164,"en":164},"BSRT Symposium in Berlin",{"de":166,"en":166},"bsrt-symposium-in-berlin",{"de":164,"en":164},"2025-12-04","2025-12-05",{"de":6,"en":171},"Berlin, Germany",{"de":6,"en":6},[174],{"title":175,"target":177},{"de":6,"en":176},"BSRT Symposium","https://bsrt.charite.de/metas/veranstaltung/veranstaltung/details/from_scars_to_strength_pioneering_research_to_support_regeneration_of_fully_functional_tissues",{"de":6,"en":6},[180],{"headline":181,"subline":183,"description":184,"text":185,"images":187,"files":188},{"de":6,"en":182},"From Scars to Strength: Pioneering research to support regeneration of fully functional tissues",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":186},"\u003Cp>We will have a \u003Cstrong>booth\u003C/strong> at the upcoming BSRT event, \u003Cbr>\u003Cem>“From Scars to Strength: Pioneering Research to Support Regeneration of Fully Functional Tissues”\u003C/em>, \u003Cbr>held at Charité Berlin.\u003C/p>\u003Cp>Visit us to discover how our high-quality plasmid and minicircle DNA solutions can support your gene and cell therapy projects, from innovative research through to GMP-compliant manufacturing.\u003C/p>\u003Cp>Stop by our booth to connect with our experts and explore how we can help advance your regenerative medicine and tissue engineering efforts.\u003C/p>\u003Cp>Want to schedule a meeting in advance?\u003Cbr>Contact us at \u003Ca target=\"_blank\" href=\"mailto:contact@plasmidfactory.com\" tt-mode=\"url\">contact@plasmidfactory.com\u003C/a>.\u003C/p>\u003Cp>We look forward to seeing you in Berlin!\u003C/p>",[],[],{"title":190,"slug":192,"description":194,"start":195,"end":195,"place":196,"subtitle":197,"links":198,"claim":202,"content":203},{"de":6,"en":191},"Webinar - Advancing AAV Vector Production with High-Integrity DNA Constructs",{"de":6,"en":193},"webinar-advancing-aav-vector-production-with-high-integrity-dna-constructs",{"de":191,"en":191},"2025-11-19",{"de":6,"en":126},{"de":6,"en":6},[199],{"title":200,"target":201},{"de":6,"en":131},"https://youtu.be/GzWrP90ZMU8",{"de":6,"en":6},[204],{"headline":205,"subline":207,"description":208,"text":209,"images":211,"files":219},{"de":6,"en":206},"Speaker Dr. Ram Shankar - Chief Scientific Officer, PlasmidFactory GmbH",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":210},"\u003Cp>\u003Ca target=\"_blank\" href=\"https://youtu.be/GzWrP90ZMU8\" tt-mode=\"url\">\u003Cstrong>Watch Webinar Recording\u003C/strong>\u003C/a>\u003C/p>\u003Cp>\u003C/p>\u003Cp>Efficient and reproducible AAV vector production critically depends on the quality and integrity of the DNA constructs used during transfection.\u003Cbr>PlasmidFactory provides a complete DNA solution portfolio — from classical plasmids to next-generation Minicircle DNA — enabling cleaner, safer, and more efficient AAV manufacturing across all development stages.\u003C/p>\u003Cp> \u003C/p>\u003Cp>\u003Cu>This webinar highlights:\u003C/u>\u003C/p>\u003Cp>The 2-plasmid system as a validated, cost-effective alternative to conventional 3-plasmid setups, reducing complexity while maintaining performance.\u003C/p>\u003Cp>The role of ITR integrity in achieving high vector yields and purity, and how ITRPROTECT® / ITRRESCUE® technologies safeguard full-length wt ITRs.\u003C/p>\u003Cp>The scientific and process benefits of Minicircle DNA, a bacterial backbone-free format that improves AAV genome yield, purity, and transduction efficiency\u003C/p>\u003Cp> \u003C/p>\u003Cp>Participants learn how PlasmidFactory, as a trusted European CDMO, supports all modalities — amplification of customer plasmid systems, high-integrity plasmids, and innovative Minicircles — providing flexibility today and readiness for the regulatory standards of tomorrow.\u003C/p>",[212,215],{"url":213,"alt":214},"https://api.plasmidfactory.com/storage/219/responsive-images/BILD-Ram-webinar___webp_W___WIDTH____H.webp",{"de":6,"en":206},{"url":216,"alt":217},"https://api.plasmidfactory.com/storage/233/responsive-images/BILD-AAV-Webinar___webp_W___WIDTH____H.webp",{"de":6,"en":218},"AAV Production",[220,223,226],{"file":221,"title":222},"https://api.plasmidfactory.com/storage/234/Webinar-2025-11-19-RamShankar-AdvancingAAV-final-digital.pdf",{"de":6,"en":77},{"file":224,"title":225},"https://api.plasmidfactory.com/storage/243/PlasmidFactoy_Webinar_Advancing-AAV-Vector-Production-with-High-Integrity-DNA-Constructs_11192025.pdf",{"de":6,"en":161},{"file":227,"title":228},"https://api.plasmidfactory.com/storage/244/Flyer-AAV_MC.pdf",{"de":6,"en":229},"AAV Solutions Flyer",{"title":231,"slug":234,"description":236,"start":238,"end":239,"place":240,"subtitle":242,"links":243,"claim":256,"content":257},{"de":232,"en":233},"Bio Europe in Vienna","BIO-Europe 2025 in Vienna",{"de":235,"en":235},"bio-europe-in-vienna",{"de":237,"en":233},"Bio Europe 2025 in Wien","2025-11-03","2025-11-05",{"de":6,"en":241},"Vienna, Austria",{"de":6,"en":6},[244,248,252],{"title":245,"target":247},{"de":6,"en":246},"BIO-Europe 2025","https://informaconnect.com/bioeurope/",{"title":249,"target":251},{"de":6,"en":250},"Exhibitor Profile","https://bio-europe.german-pavilion.com/en/sites/exhibitors/125927/",{"title":253,"target":255},{"de":6,"en":254},"Arrange a Meeting","https://bio-europe.german-pavilion.com/en/sites/exhibitors/125927/message",{"de":6,"en":6},[258],{"headline":259,"subline":261,"description":262,"text":263,"images":265,"files":274},{"de":6,"en":260},"German Pavilion - Booth #C114-14",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":264},"\u003Cp>We’ll be attending BIO-Europe and are happy to meet and connect! You can find us at the \u003Ca target=\"_blank\" href=\"https://bio.nrw.de/\" tt-mode=\"url\">\u003Cstrong>Bio.NRW\u003C/strong>\u003C/a>\u003Cstrong> joint booth #C114-14\u003C/strong> at the German Pavilion.\u003Cbr>Let’s talk about how our high-quality plasmid and Minicircle DNA can support your gene and cell therapy projects - from research to GMP.\u003C/p>\u003Cp>Would you like to connect with us in Vienna? Book a meeting with our team \u003Ca target=\"_blank\" href=\"https://bio-europe.german-pavilion.com/en/sites/exhibitors/125927/message\" tt-mode=\"url\">\u003Cstrong>HERE\u003C/strong>\u003C/a>\u003C/p>\u003Cp>Find our exhibitor profile on the \u003Ca target=\"_new\" rel=\"noopener\" class=\"decorated-link\" href=\"https://bio-europe.german-pavilion.com/en/sites/exhibitors/125927\" tt-mode=\"url\">\u003Cstrong>German Pavilion website\u003C/strong>\u003C/a> for more information about PlasmidFactory’s participation.\u003C/p>\u003Cp>The event brings together decision-makers from biotechnology, pharma, and finance to foster innovation and collaboration across the life sciences industry.\u003Cbr>Learn more about the event on the \u003Ca target=\"_new\" rel=\"noopener\" class=\"decorated-link\" href=\"https://informaconnect.com/bioeurope/\" tt-mode=\"url\">\u003Cstrong>official BIO-Europe website\u003C/strong>\u003C/a>\u003C/p>",[266,270],{"url":267,"alt":268},"https://api.plasmidfactory.com/storage/182/responsive-images/BILD-Wien-2025___webp_W___WIDTH____H.webp",{"de":6,"en":269},"Visual from Vienna",{"url":271,"alt":272},"https://api.plasmidfactory.com/storage/183/responsive-images/BILD-Wien-logo-2025___webp_W___WIDTH____H.webp",{"de":6,"en":273},"BIO-Europe in Vienna",[],{"title":276,"slug":278,"description":280,"start":283,"end":284,"place":285,"subtitle":287,"links":289,"claim":294,"content":295},{"de":6,"en":277},"ESGCT, 2025 – 32st Annual Congress in Seville",{"de":6,"en":279},"esgct-2025-32st-annual-congress-in-sevilla",{"de":281,"en":282},"ESGCT 2025 in Sevilla mit Stand und Lunch Time Symposium","ESGCT 2025 in Sevilla with Booth and Lunchtime Symposium","2025-10-07","2025-10-10",{"de":6,"en":286},"Seville/Spain",{"de":6,"en":288},"Booth &  Lunchtime Symposium",[290],{"title":291,"target":293},{"de":6,"en":292},"ESGCT 2025","https://www.esgctcongress.com/",{"de":6,"en":6},[296],{"headline":297,"subline":299,"description":300,"text":301,"images":304,"files":313},{"de":6,"en":298},"Booth #B21/B22",{"de":6,"en":6},{"de":6,"en":6},{"de":302,"en":303},"\u003Cp>\u003Cstrong>Join us at the Annual Congress of the European Society of Gene and Cell Therapy (ESGCT) in Seville!\u003C/strong>\u003C/p>\u003Cp>Visit us at \u003Cstrong>booth B21/B22\u003C/strong> to discover how our high-quality \u003Cstrong>plasmid and Minicircle DNA\u003C/strong> support gene and cell therapy programs from \u003Cstrong>research to GMP\u003C/strong>. With more than \u003Cstrong>25 years of experience\u003C/strong>, PlasmidFactory is your trusted partner for \u003Cstrong>complex constructs and regulatory-grade DNA\u003C/strong>. \u003C/p>\u003Cp>\u003C/p>\u003Cp>\u003Cstrong>Lunch Symposium\u003C/strong>\u003C/p>\u003Cp>\u003Cstrong>\"Virus-free genetic engineering using Minicircles for scalable & effective cell therapies“\u003C/strong>\u003Cbr>Wednesday, October 08 | 01:30–02:30 PM | Room Parallel A\u003C/p>\u003Cp>Our symposium will feature five distinguished speakers bringing \u003Cstrong>cutting-edge perspectives from global CGT innovators\u003C/strong>:\u003C/p>\u003Cul>\u003Cli>\u003Cp>\u003Cstrong>Prof. Dr. Michael Hudecek\u003C/strong> (Chair, University of Würzburg) – \u003Cem>Minicircle-based CAR-T: clinical applications\u003C/em>\u003C/p>\u003C/li>\u003Cli>\u003Cp>\u003Cstrong>Prof. Dr. Zoltán Ivics\u003C/strong> (University of Leipzig) – \u003Cem>Sleeping Beauty engineering with Minicircle vectors\u003C/em>\u003C/p>\u003C/li>\u003Cli>\u003Cp>\u003Cstrong>Dr. Volker Lennerz\u003C/strong> (TheryCell GmbH, Berlin) – \u003Cem>Non-viral manufacturing of tumor-specific TCR-T cells\u003C/em>\u003C/p>\u003C/li>\u003Cli>\u003Cp>\u003Cstrong>Dr. Juan R. Rodriguez-Madoz\u003C/strong> (University of Navarra, Spain) – \u003Cem>Transposon-based non-viral vectors for CAR-T\u003C/em>\u003C/p>\u003C/li>\u003Cli>\u003Cp>\u003Cstrong>Dr. Ulf Grawunder\u003C/strong> (T-CurX GmbH, Würzburg) – \u003Cem>Promises & challenges of in vivo CAR-T therapies\u003C/em>\u003C/p>\u003C/li>\u003C/ul>\u003Cp>\u003C/p>\u003Cp>\u003Cstrong>Let’s connect in Seville!\u003C/strong>\u003C/p>\u003Cp>We look forward to meeting you at ESGCT – whether at our \u003Cstrong>booth\u003C/strong> or during our \u003Cstrong>Lunch Symposium\u003C/strong>.\u003Cbr>\u003Cstrong>Reach out to schedule a meeting in advance:\u003C/strong> \u003Ca target=\"_blank\" href=\"mailto:contact@plasmidfactory.com\" tt-mode=\"url\">contact@plasmidfactory.com\u003C/a>. \u003C/p>","\u003Cp>\u003Cstrong>Join us at the Annual Congress of the European Society of Gene and Cell Therapy (ESGCT) in Seville!\u003C/strong>\u003C/p>\u003Cp>Visit us at \u003Cstrong>booth B21/B22\u003C/strong> to discover how our high-quality \u003Cstrong>plasmid and Minicircle DNA\u003C/strong> support gene and cell therapy programs from \u003Cstrong>research to GMP\u003C/strong>. With more than \u003Cstrong>25 years of experience\u003C/strong>, PlasmidFactory is your trusted partner for \u003Cstrong>complex constructs and regulatory-grade DNA\u003C/strong>. \u003C/p>\u003Cp>\u003C/p>\u003Cp>\u003Cstrong>Lunch Symposium\u003C/strong>\u003Cbr>\u003Cstrong>\"Virus-free genetic engineering using Minicircles for scalable & effective cell therapies“\u003C/strong>\u003Cbr>October 08 | 01:30–02:30 PM | Room Parallel A\u003C/p>\u003Cp>Our symposium will feature five distinguished speakers bringing \u003Cstrong>cutting-edge perspectives from global CGT innovators\u003C/strong>:\u003C/p>\u003Cul>\u003Cli>\u003Cp>\u003Cstrong>Prof. Dr. Michael Hudecek\u003C/strong> (Chair, University of Würzburg) – \u003Cem>Minicircle-based CAR-T: clinical applications\u003C/em>\u003C/p>\u003C/li>\u003Cli>\u003Cp>\u003Cstrong>Prof. Dr. Zoltán Ivics\u003C/strong> (University of Leipzig) – \u003Cem>Sleeping Beauty engineering with Minicircle vectors\u003C/em>\u003C/p>\u003C/li>\u003Cli>\u003Cp>\u003Cstrong>Dr. Volker Lennerz\u003C/strong> (TheryCell GmbH, Berlin) – \u003Cem>Non-viral manufacturing of tumor-specific TCR-T cells\u003C/em>\u003C/p>\u003C/li>\u003Cli>\u003Cp>\u003Cstrong>Dr. Juan R. Rodriguez-Madoz\u003C/strong> (University of Navarra, Spain) – \u003Cem>Transposon-based non-viral vectors for CAR-T\u003C/em>\u003C/p>\u003C/li>\u003Cli>\u003Cp>\u003Cstrong>Dr. Ulf Grawunder\u003C/strong> (T-CurX GmbH, Würzburg) – \u003Cem>Promises & challenges of in vivo CAR-T therapies\u003C/em>\u003C/p>\u003C/li>\u003C/ul>\u003Cp>\u003C/p>\u003Cp>\u003Cstrong>Let’s connect in Seville!\u003C/strong>\u003Cbr>We look forward to meeting you at ESGCT – whether at our \u003Cstrong>booth\u003C/strong> or during our \u003Cstrong>Lunch Symposium\u003C/strong>.\u003Cbr>\u003Cstrong>Reach out to schedule a meeting in advance:\u003C/strong> \u003Ca target=\"_blank\" href=\"mailto:contact@plasmidfactory.com\" tt-mode=\"url\">contact@plasmidfactory.com\u003C/a>. \u003C/p>",[305,309],{"url":306,"alt":307},"https://api.plasmidfactory.com/storage/178/responsive-images/ESGCT-visual1-2025___webp_W___WIDTH____H.webp",{"de":6,"en":308},"Plaza de Espana",{"url":310,"alt":311},"https://api.plasmidfactory.com/storage/179/responsive-images/ESGCT-visual2-2025___webp_W___WIDTH____H.webp",{"de":6,"en":312},"ESGCT-Logo",[314],{"file":315,"title":316},"https://api.plasmidfactory.com/storage/187/TakeAway-LunchSymposium-2025-09-06-final.pdf",{"de":6,"en":317},"Download agenda flyer here ",{"title":319,"slug":321,"description":323,"start":325,"end":326,"place":327,"subtitle":329,"links":331,"claim":336,"content":337},{"de":320,"en":320},"10th CAR-TCR Summit in Boston",{"de":322,"en":322},"10th-car-tcr-summit",{"de":324,"en":320},"10th CAR-TCR Summit","2025-09-23","2025-09-26",{"de":6,"en":328},"Boston, MA/USA",{"de":330,"en":330},"Poster “Minicircles as key starting materials to enable non-viral engineering of T lymphocytes for gene-modified cell therapies”",[332],{"title":333,"target":335},{"de":6,"en":334},"10th CAR-TCR Summit ","https://car-tcr-summit.com/",{"de":6,"en":6},[338,357],{"headline":339,"subline":341,"description":342,"text":343,"images":345,"files":352},{"de":6,"en":340},"Booth #10",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":344},"\u003Cp>We are excited to be part of the \u003Cstrong>10th CAR-TCR Summit in Boston\u003C/strong>, bringing together leaders and innovators in cell and gene therapy. As a trusted manufacturer of high-quality Plasmid and Minicircle DNA, PlasmidFactory supports the development of CAR-T and TCR therapies with customized DNA solutions – from research to clinical applications and commercial manufacturing.\u003C/p>\u003Cp>Our mission: \u003Cstrong>enable safe, scalable, and viral-free engineering of immune cells\u003C/strong> to accelerate the future of advanced therapies.\u003C/p>\u003Cp> \u003C/p>\u003Cp>\u003Cstrong>Scientific Contribution\u003C/strong>\u003C/p>\u003Cp>\u003Cstrong>Poster Presentation\u003C/strong>\u003Cbr>\u003Cstrong>“Minicircles as key starting materials to enable non-viral engineering of T lymphocytes for gene-modified cell therapies”\u003C/strong>\u003Cbr>\u003Cem>Ram Shankar, Marco Schmeer, Martin Schleef & Dirk Winnemöller (presenting author)\u003C/em>\u003C/p>\u003Cp>Our poster highlights how Minicircle DNA provides a powerful foundation for efficient, safe, and regulatory-friendly non-viral engineering of T cells – paving the way for next-generation CAR-T and CAR-NK therapies.\u003Cbr>-> \u003Cspan>Poster #16 I Tuesday 23rd Cellares poster session 6 pm I Wednesday 24th exhibition area all day\u003C/span>\u003C/p>\u003Cp> \u003C/p>\u003Cp>\u003Cstrong>Meet Us in Boston\u003C/strong>\u003Cbr>We look forward to connecting with you at the CAR-TCR Summit:\u003C/p>\u003Cp>\u003Cstrong>• Visit Booth #10\u003C/strong> – Discover how our plasmid and Minicircle solutions can accelerate your therapy development\u003C/p>\u003Cp>\u003Cstrong>• Meet our CEO\u003C/strong> – Schedule a meeting with Dr. Dirk Winnemöller to discuss your projects and challenges.\u003C/p>\u003Cp>\u003Cstrong>• Schedule a meeting in advance:\u003C/strong> \u003Ca target=\"_blank\" href=\"mailto:contact@plasmidfactory.com\" tt-mode=\"url\">\u003Cu>contact@plasmidfactory.com\u003C/u>\u003C/a>\u003C/p>\u003Cp>\u003Cstrong>• Check out our Poster\u003C/strong> – Learn more about how Minicircles are shaping the future of viral-free cell engineering\u003C/p>",[346,349],{"url":347,"alt":348},"https://api.plasmidfactory.com/storage/184/responsive-images/BILD-Boston1-2025___webp_W___WIDTH____H.webp",{"de":6,"en":6},{"url":350,"alt":351},"https://api.plasmidfactory.com/storage/186/responsive-images/BILD-Boston2-2025___webp_W___WIDTH____H.webp",{"de":6,"en":6},[353],{"file":354,"title":355},"https://api.plasmidfactory.com/storage/263/GMCT-Poster.pdf",{"de":6,"en":356},"Safer, Scalable T Cell Engineering - Poster Presentation",{"headline":358,"subline":359,"description":360,"text":361,"images":363,"files":364},{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":362},"\u003Cp>\u003C/p>",[],[],{"title":366,"slug":368,"description":370,"start":373,"end":374,"place":375,"subtitle":377,"links":378,"claim":383,"content":384},{"de":6,"en":367},"BIO International Convention 2025 in Boston",{"de":6,"en":369},"bio-international-convention-2025",{"de":371,"en":372},"Wir sind auf der BIO International Convention 2025","We attend at BIO International Convention 2025","2025-06-16","2025-06-19",{"de":6,"en":376},"Boston/USA",{"de":6,"en":6},[379],{"title":380,"target":382},{"de":6,"en":381},"BIO International","https://convention.bio.org/bio-2025",{"de":6,"en":6},[385],{"headline":386,"subline":388,"description":389,"text":390,"images":392,"files":401},{"de":6,"en":387},"Visit us at the GermanPavilion",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":391},"\u003Cp>\u003Cstrong>PlasmidFactory at BIO International 2025\u003C/strong>\u003C/p>\u003Cp>We’re excited to exhibit at BIO2025 in Boston, June 16-19, as part of the German Pavilion community booth.\u003C/p>\u003Cp>PlasmidFactory is your expert CDMO for Research-, GMP- and High Quality-Grade plasmid and minicircle DNA, tailored to power AAV production, CAR-T cell development, and mRNA manufacturing. Our advanced technologies – such as enzyme-free plasmids and minicircles – ensure high purity, regulatory compliance, and optimized performance for your therapeutic platforms.\u003C/p>\u003Cp>Let’s talk about how our DNA can support your next breakthrough.\u003C/p>\u003Cp>Visit us at the GermanPavilion or contact us at \u003Ca target=\"_blank\" href=\"mailto:contact@plasmidfactory.com\" tt-mode=\"url\">info@plasmidfactory.com\u003C/a> to discuss how we can support your application.\u003C/p>",[393,397],{"url":394,"alt":395},"https://api.plasmidfactory.com/storage/175/responsive-images/BIO-international-visual1-2025___webp_W___WIDTH____H.webp",{"de":6,"en":396},"Boston Skyline",{"url":398,"alt":399},"https://api.plasmidfactory.com/storage/177/responsive-images/BIO-international-visual2-2025___webp_W___WIDTH____H.webp",{"de":6,"en":400},"Bio International",[],{"title":403,"slug":405,"description":407,"start":410,"end":411,"place":412,"subtitle":414,"links":415,"claim":419,"content":420},{"de":6,"en":404},"ASGCT 2025, 28th Annual Meeting in New Orleans",{"de":6,"en":406},"asgct-2025",{"de":408,"en":409},"PlasmidFactory ist auf der ASGCT 2025 mit einem Stand und 2 Vorträgen vertreten","PlasmidFactory is represented at ASGCT 2025 with a booth and 2 presentations","2025-05-13","2025-05-17",{"de":6,"en":413},"New Orleans",{"de":6,"en":6},[416],{"title":417,"target":20},{"de":6,"en":418},"ASGCT",{"de":6,"en":6},[421],{"headline":422,"subline":424,"description":425,"text":426,"images":428,"files":437},{"de":6,"en":423},"Booth #644 and 2 Presentations",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":427},"\u003Cp>PlasmidFactory can’t wait to connect with you at the 28\u003Csup>th\u003C/sup> Annual Meeting of the ASGCT in New Orleans!\u003C/p>\u003Cp>\u003Cstrong>Discover Our Booth\u003C/strong>\u003Cbr>Stop by our booth #644 to explore how our high-quality plasmid DNA and proprietary minicircle DNA can empower your cell and gene therapy projects. While you’re there, be sure to grab some of our exciting new merchandise, available exclusively at ASGCT 2025!\u003C/p>\u003Cp>\u003Cstrong>Don’t Miss Our Presentations\u003C/strong>\u003Cbr>\u003Cspan>Learn about our latest advancements and research in critical quality aspect of ITR sequence length in AAV transfer plasmids during the conference. Stay tuned for updates in the Tools & Tech talk (“\u003C/span>\u003Cstrong>\u003Cspan>New transfer vectors for your rAAV production”\u003C/span>\u003C/strong>\u003Cspan>) on May 14\u003Csup>th\u003C/sup>, 4:45pm and the oral presentation (“\u003C/span>\u003Cstrong>\u003Cspan>Stable maintenance of full-length ITRs in AAV transfer plasmids\u003C/span>”\u003C/strong>\u003Cspan>) on May 15\u003Csup> th\u003C/sup>,5:00 pm in the NOLA Theater C – you won’t want to miss these!\u003C/span>\u003C/p>\u003Cp>\u003Cstrong>Celebrate 25 years of PlasmidFactory\u003C/strong>\u003Cbr>PlasmidFactory is proudly announcing its 25\u003Csup>th\u003C/sup> anniversary! Celebrate 25 years full of innovation and scientific progress in DNA production and purification with us – be prepared for a few surprises!\u003C/p>\u003Cp>\u003Cstrong>We’re looking forward to connecting with you in New Orleans! \u003C/strong>\u003Cbr>To schedule a meeting, please send an email to \u003Ca target=\"_blank\" href=\"mailto:contact@plasmidfactory.com\" tt-mode=\"url\">contact@plasmidfactory.com\u003C/a>.\u003C/p>",[429,433],{"url":430,"alt":431},"https://api.plasmidfactory.com/storage/172/responsive-images/ASGCT-2025___webp_W___WIDTH____H.webp",{"de":6,"en":432},"Visual New Orleans",{"url":434,"alt":435},"https://api.plasmidfactory.com/storage/174/responsive-images/ASGCT-2025x___webp_W___WIDTH____H.webp",{"de":6,"en":436},"Logo ASGCT New Orleans",[],{"title":439,"slug":441,"description":443,"start":445,"end":446,"place":447,"subtitle":449,"links":450,"claim":454,"content":455},{"de":6,"en":440},"Swiss Biotech Day",{"de":6,"en":442},"swiss-biotech-day",{"de":444,"en":444},"PlasmidFactory's scientists at Swiss Biotech Day","2025-05-05","2025-05-06",{"de":6,"en":448},"Basel/Switzerland",{"de":6,"en":6},[451],{"title":452,"target":453},{"de":6,"en":440},"https://swissbiotechday.ch/",{"de":6,"en":6},[456],{"headline":457,"subline":459,"description":460,"text":461,"images":463,"files":472},{"de":6,"en":458},"Booth # 9",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":462},"\u003Cp>\u003Cspan>PlasmidFactory is proud to exhibit at Swiss Biotech Day 2025, taking place on May 5-6 at the Congress Center Basel. As one of the leading suppliers of high-quality plasmid DNA and proprietary minicircle DNA, we’re excited to showcase our solutions for your AAV, CART and mRNA projects at our booth # 9.\u003C/span>\u003C/p>\u003Cp>\u003Cspan>Don’t miss the chance to visit our booth and take advantage of our “Risk free testing of Minicircles” program!\u003C/span>\u003C/p>\u003Cp>\u003Cspan>To schedule a meeting, contact us via \u003C/span>\u003Ca target=\"_blank\" href=\"mailto:contact@plasmidfactory.com\" tt-mode=\"url\">\u003Cspan>contact@plasmidfactory.com\u003C/span>\u003C/a>\u003Cspan>. \u003Cbr>We look forward to welcoming you to Basel.\u003C/span>\u003C/p>",[464,469],{"url":465,"alt":466},"https://api.plasmidfactory.com/storage/170/responsive-images/Swissbiotechday2025-in-Basel___webp_W___WIDTH____H.webp",{"de":467,"en":468},"Baseler Münster und Rhein","Cathedral in Basel and Rhine",{"url":470,"alt":471},"https://api.plasmidfactory.com/storage/171/responsive-images/Swissbiotechday2025___webp_W___WIDTH____H.webp",{"de":440,"en":440},[],{"title":474,"slug":476,"description":478,"start":481,"end":482,"place":483,"subtitle":485,"links":486,"claim":490,"content":491},{"de":6,"en":475},"D.B.T. German Biotech Days",{"de":6,"en":477},"dbt-german-biotech-days",{"de":479,"en":480},"PlasmidFactory is thrilled to announce our participation in the GermanBiotechDays 2025. Discuss with our experts about advances in GCT, Genetic Vaccination","We are with coffeeon and booth at the German Biotech Days 2025. Discuss with our experts about advances in GCT, Genetic Vaccination","2025-04-09","2025-04-10",{"de":6,"en":484},"Heidelberg/Germany",{"de":6,"en":6},[487],{"title":488,"target":489},{"de":6,"en":475},"https://www.german-biotech.day/",{"de":6,"en":6},[492],{"headline":493,"subline":495,"description":496,"text":497,"images":499,"files":506},{"de":6,"en":494},"  Booth at BIO NRW 24 – 27",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":498},"\u003Cp>\u003Cstrong>Meet us in Heidelberg!\u003C/strong>\u003Cbr>PlasmidFactory is thrilled to announce our participation in the German Biotech Days 2025  taking place in Heidelberg on April 9-10. As a leading contract manufacturer specializing in plasmid DNA and minicircle DNA, we are eager to engage with industry experts to discuss advancements in gene therapy and cell therapy, genetic vaccination, and bio-economy applications.\u003C/p>\u003Cp>DBT 2025 serves as a premier forum for the biotechnology sector, uniting entrepreneurs, scientists, policymakers, investors, and funding institutions to explore the vast potential of biotechnology across various fields. Our high-quality plasmid and minicircle DNA products are designed to support innovations in health research and beyond, aligning seamlessly with the event's objectives.\u003C/p>\u003Cp>We invite attendees of DBT 2025 to visit our booth 24-27 and join our coffeeon at 10.04.2025 with Dr. Marco Schmeer to learn how PlasmidFactory can drive your projects forward. Please contact us \u003Ca target=\"_blank\" href=\"mailto:contact@plasmidfactory.com\" tt-mode=\"url\">contact@plasmidfactory.com\u003C/a> to schedule a meeting.\u003Cbr>\u003Cstrong>We look forward to meaningful discussions and collaborations in Heidelberg!\u003C/strong>\u003C/p>",[500,503],{"url":501,"alt":502},"https://api.plasmidfactory.com/storage/168/responsive-images/DBT25-Heidelberg-Schloss-HP___webp_W___WIDTH____H.webp",{"de":6,"en":6},{"url":504,"alt":505},"https://api.plasmidfactory.com/storage/169/responsive-images/DBT25-Logo-HP___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"title":508,"slug":510,"description":512,"start":515,"end":516,"place":517,"subtitle":519,"links":520,"claim":525,"content":526},{"de":6,"en":509},"DCAT Week",{"de":6,"en":511},"dcat-week",{"de":513,"en":514},"PlasmidFactory wird auf der DCAT Week sein, um strategische Beziehungen zur Unterstützung ihrer DNA-Lieferkette zu knüpfen.","PlasmidFactory will be at DCAT Week meeting with drug developers and CDMOs to forge strategic relationships to support their DNA supply chain needs.","2025-03-17","2025-03-20",{"de":6,"en":518},"New York City/USA",{"de":6,"en":6},[521],{"title":522,"target":524},{"de":6,"en":523},"DCAT week","https://dcatweek.org/",{"de":6,"en":6},[527],{"headline":528,"subline":529,"description":530,"text":531,"images":533,"files":534},{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":532},"\u003Cp>PlasmidFactory will be at DCAT Week meeting with drug developers and CDMOs to forge strategic relationships to support their DNA supply chain needs. PlasmidFactory is a premier supplier of plasmid DNA and our proprietary minicircle DNA. If you are attending DCAT week and want to know how PlasmidFactory can support your processes, please send an email to: \u003Ca target=\"_blank\" href=\"mailto:contact@plasmidfactory.com\" tt-mode=\"url\">contact@plasmidfactory.com\u003C/a>. \u003Cbr>\u003Cstrong>We look forward to meeting you in NYC!\u003C/strong>\u003C/p>",[],[],{"title":536,"slug":538,"description":540,"start":543,"end":544,"place":545,"subtitle":547,"links":548,"claim":553,"content":554},{"de":6,"en":537},"BioProcessingDays",{"de":6,"en":539},"bioprocessingdays",{"de":541,"en":542},"Als CDMO von hochwertiger DNA unterstreicht unser Sponsoring von dasr Engagement für die Förderung von Bioprozessinnovationen","As a CDMO of high quality DNA, our sponsorship of ther underlines our commitment to promoting bioprocess innovation","2025-02-24","2025-02-26",{"de":6,"en":546},"Recklinghausen/ Germany",{"de":6,"en":6},[549],{"title":550,"target":552},{"de":6,"en":551},"BPD 2025","http://www.apz-rl.de/",{"de":6,"en":6},[555],{"headline":556,"subline":558,"description":559,"text":560,"images":562,"files":566},{"de":6,"en":557},"BioProcessingDays 2025",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":561},"\u003Cp>\u003Cspan>PlasmidFactory is proud to be one of the sponsors for the 8th BioProcessingDays, themed \"Innovative Bioprocess Technology,\" scheduled for February 24-26, 2025, at the Westfalian University of Applied Sciences in Recklinghausen.\u003C/span>\u003C/p>\u003Cp>\u003Cspan>This event focuses on cutting-edge developments in bioprocess technology, including precision fermentation and automated process control, which are pivotal in optimizing biological systems for industrial production.\u003C/span>\u003C/p>\u003Cp>\u003Cspan>As a leading supplier of high-quality plasmid and minicircle DNA, PlasmidFactory's sponsorship underscores our commitment to advancing bioprocess innovations that drive sustainable and efficient production methods across various industries. If you are interested in learning more about pDNA and mcDNA, please do not hesitate to contact us via \u003C/span>\u003Ca target=\"_blank\" href=\"mailto:contact@plasmidfactory.com\" tt-mode=\"url\">\u003Cspan>contact@plasmidfactory.com\u003C/span>\u003C/a>\u003Cspan>.\u003C/span>\u003C/p>",[563],{"url":564,"alt":565},"https://api.plasmidfactory.com/storage/165/responsive-images/BILD-BPD-25___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"title":568,"slug":570,"description":572,"start":575,"end":576,"place":577,"subtitle":579,"links":580,"claim":581,"content":582},{"de":6,"en":569},"Advanced Therapies Week (Phacilitate)",{"de":6,"en":571},"advanced-therapies-week",{"de":573,"en":574},"Unsere Kunden sind von unserer Plasmid- und Minicircle-DNA begeistert, und wir möchten Ihnen zeigen, wie Sie mit unserer DNA Zeit und Geld sparen können","Our clients love the quality of our plasmid DNA and minicircle DNA and we’d like to show you how our DNA can save you time and money","2025-01-20","2025-01-23",{"de":6,"en":578},"Dallas/USA",{"de":6,"en":6},[],{"de":6,"en":6},[583],{"headline":584,"subline":586,"description":587,"text":588,"images":590,"files":591},{"de":6,"en":585},"Advanced Therapies Week (Phacilitate) is coming up fast! ",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":589},"\u003Cp>PlasmidFactory will be in Sunny Dallas January 20-23 to meet with drug developers and CDMOs to learn about their DNA supply chain needs. Our clients love the quality of our plasmid DNA and minicircle DNA and we’d like to \u003Cstrong>s\u003C/strong>how you how our DNA can save you time and money. If you are attending and want to know more about our business, please send an email to: \u003Ca target=\"_blank\" href=\"mailto:contact@plasmidfactory.com\" tt-mode=\"url\">contact@plasmidfactory.com\u003C/a>\u003Cbr>\u003Cbr>\u003C/p>",[],[],{"title":593,"slug":595,"description":597,"start":600,"end":601,"place":602,"subtitle":604,"links":606,"claim":607,"content":608},{"de":6,"en":594},"BSRT – 15th BSRT Symposium",{"de":6,"en":596},"bsrt",{"de":598,"en":599},"Nehmen Sie an der Präsentation von Dr. Marco Schmeer an der BSRT teil","Join Dr. Marco Schmeer's Presentation slot at The Berlin School for Regenerative Therapies","2024-12-05","2024-12-06",{"de":6,"en":603},"Berlin/Germany",{"de":6,"en":605},"15th BSRT Symposium",[],{"de":6,"en":6},[609],{"headline":610,"subline":612,"description":613,"text":614,"images":616,"files":623},{"de":6,"en":611},"United by Translation: Towards Novel Paths in Regenerative Medicine",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":615},"\u003Cp>\u003Cstrong>Join Dr. Marco Schmeer's Presentation slot on the 05.12.2024, between 15.30 and 16:15, or visit us at the PlasmidFactory exhibition booth.\u003C/strong>\u003C/p>\u003Cp>\u003C/p>\u003Cp>The Berlin School for Regenerative Therapies (BSRT, graduate school 203 of the German \u003Ca target=\"_blank\" class=\"external-link\" href=\"http://www.dfg.de/en/research_funding/programmes/excellence_initiative/index.html\" tt-mode=\"url\">Excellence Initiative\u003C/a>) offers interdisciplinary training and research opportunities in the field of Regenerative Medicine for outstanding doctoral researchers with a background in the biological, engineering or clinical disciplines. Young scientists at the BSRT work within a strong and intellectually stimulating \u003Ca target=\"_blank\" class=\"internal-link\" href=\"https://bsrt.charite.de/network/\" tt-mode=\"url\">network of institutions\u003C/a> and scientists.\u003C/p>",[617,620],{"url":618,"alt":619},"https://api.plasmidfactory.com/storage/119/responsive-images/BILD-BSRT-Logo___webp_W___WIDTH____H.webp",{"de":6,"en":6},{"url":621,"alt":622},"https://api.plasmidfactory.com/storage/120/responsive-images/BILD-BSRT-Symposium___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"title":625,"slug":628,"description":630,"start":633,"end":634,"place":635,"subtitle":637,"links":639,"claim":640,"content":641},{"de":626,"en":627},"Bio Europe, 2024","Bio Europe, 2024 – Part of the German Pavillon",{"de":629,"en":629},"bio-europe-2024",{"de":631,"en":632},"PlasmidFactory wird auf der BioEurope in Stockholm vertreten sein","PlasmidFactory will be present at BioEurope in Stockholm","2024-11-04","2024-11-06",{"de":6,"en":636},"Stockholm/Sweden",{"de":638,"en":6},"with a Booth at the German Pavillon",[],{"de":6,"en":6},[642],{"headline":643,"subline":645,"description":646,"text":647,"images":649,"files":656},{"de":6,"en":644},"Booth 180-26",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":648},"\u003Cp>\u003Cstrong>After Rome is before Stockholm!\u003C/strong>\u003Cbr>We’re thrilled to announce that PlasmidFactory will be present at BioEurope in Stockholm for the first time!\u003C/p>\u003Cp>Join our colleagues \u003Cstrong>Adriana Voth\u003C/strong> and \u003Cstrong>Gina Cheung\u003C/strong> at the German Pavilion with booth number 180-26, where they’ll be ready to answer all your questions.\u003C/p>\u003Cp>If you like to connect, reach out and schedule a meeting through the partnering portal today!\u003C/p>\u003Cp>Looking forward to seeing you there!\u003C/p>",[650,653],{"url":651,"alt":652},"https://api.plasmidfactory.com/storage/60/responsive-images/BIO-Europe___webp_W___WIDTH____H.webp",{"de":6,"en":6},{"url":654,"alt":655},"https://api.plasmidfactory.com/storage/61/responsive-images/Stockholm___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"title":658,"slug":661,"description":664,"start":667,"end":668,"place":669,"subtitle":671,"links":674,"claim":679,"content":681},{"de":659,"en":660},"ESGCT, 2024 – Booth follows","ESGCT, 2024 – 31st Annual Congress in Rome",{"de":662,"en":663},"esgct-2024-booth-follows","ESGCT2024",{"de":665,"en":666},"Ein Spotlight auf Plasmid- und Minicircle-DNA-Ausgangsmaterialien für AAV-Vektoren.  Nehmen Sie an unserem Mittagssymposium teil!","A spotlight on plasmid and minicircle DNA starting materials for AAV vectors.  Join our lunch symposium!","2024-10-22","2024-10-25",{"de":6,"en":670},"Rome/Italy",{"de":672,"en":673},"31th Annual Congress with Lunch Time Symposium","PlasmidFactory will be present with a booth and organize a lunchtime symposium!",[675],{"title":676,"target":678},{"de":6,"en":677},"ESGCT 2024","https://www.esgctcongress.com/programme-wed",{"de":6,"en":680},"Top quality dishes require  top quality ingredients:  Plasmid & minicircle DNA for your AAV needs!",[682,699],{"headline":683,"subline":685,"description":686,"text":687,"images":689,"files":698},{"de":6,"en":684},"Booth B21/22",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":688},"\u003Cp>\u003Cstrong>A spotlight on plasmid and minicircle DNA starting materials for AAV vectors\u003C/strong>\u003C/p>\u003Cp>Join our lunch symposium on Wednesday, Oct 23rd, 1:30 p.m., Meeting Room 1 about challenges and \u003Cbr>opportunities in AAV-based Gene Therapy and get insights from our experienced speakers.\u003C/p>\u003Cp>\u003Cem>Organized by PlasmidFactory GmbH\u003C/em>\u003C/p>\u003Cp>For AAV vector production, a broad range of developments is reported in vector design, cell culture conditions and chromatographic purifications. Many of these important breakthroughs have successfully pushed the volumetric yield as well vector product quality in the last few years. However, due attention is often not paid to the starting materials involved in any AAV vector production – the plasmid DNA carrying ITR-flanked cargo, the packaging genes and the adenoviral helper genes. The specific design of these constructs can have direct consequences to the AAV vector product. Based on the philosophy that good products can only come from good materials, a high titer and well-defined quality of recombinant AAV vectors would require correspondingly well-defined high quality starting material in the form of plasmid or minicircle DNA. In this symposium, we would like to draw attention to certain important features that one would want to look at when working with those humble and often overlooked molecules where it all starts from – the plasmid DNA.\u003C/p>\u003Cp>Firstly, the conventional triple transfection protocol for AAV production has been a hallmark scientific development that formed the basis of realizing the goal of engineering the wild type virus into a recombinant vector particle. Reducing the number of plasmid constructs required for an industrial AAV vector production offers advantages in process optimization, development as well as reducing manufacturing costs involved and thus offers to considerably bring down the price of the final gene therapy product. The recent trend has been to combine features in any of the different combinations possible. One of the earliest developments in this direction came from German Cancer Research Centre through the creation of the pDG series of plasmids. This led to the development of a 2-plasmid system for AAV production which has been successfully used by researchers around the world for several years. Scientists at Reithera in Italy have used this system and followed a rational optimization plan for their conditions and will be reporting their findings during this lunch symposium.\u003C/p>\u003Cp>\u003C/p>",[690,694],{"url":691,"alt":692},"https://api.plasmidfactory.com/storage/62/responsive-images/ESGCT_Rome24___webp_W___WIDTH____H.webp",{"de":6,"en":693},"ESGCT Congress",{"url":695,"alt":696},"https://api.plasmidfactory.com/storage/137/responsive-images/2024-ESGCT-LunchSymp-web___webp_W___WIDTH____H.webp",{"de":6,"en":697},"LunchSymposium",[],{"headline":700,"subline":701,"description":702,"text":703,"images":705,"files":706},{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":704},"\u003Cp>The 2-plasmid system consists of a transfer vector carrying the ITR sequences which flank the gene cargo. The cargo could either be a reporter gene or a therapeutic gene for the intended application. The second plasmid is a Helper and Packaging plasmid containing the rep and cap genes as well as the adenoviral helper genes. Further important aspects to discuss include the possibility to deliver large quantities in High Quality Grade and as in-stock (off the shelf) products which would greatly ease manufacturing challenges during vector production. The use of HQ plasmid DNA allows for the GMP manufacturing of AAV vector products up to the early-stage clinical trial phases.\u003C/p>\u003Cp>One major drawback in using plasmid DNA as a transfer vector is the issue of retropackaging of plasmid backbone sequences into a fraction of the recombinant AAV vectors. Significant results were first reported from workers at University of Cologne, wherein the value of using minicircle DNA devoid of prokaryotic backbone sequences became evident in that the resulting AAV vector preparations were essentially free of any prokaryotic DNA contamination. This represented a tremendous leap in AAV vector quality and sets the stage for future vector preparations suitable for clinical grade materials.\u003C/p>\u003Cp>Finally, we examine the Inverted Terminal Repeats of AAV in greater detail. This crucial genetic structure needs to be faithfully supplied in the plasmid template to be reliably built into the rAAV genome. Failure to do so results in sub-optimal AAV yields and packaging efficiency, show researchers at the Bielefeld University. These elements are challenging to propagate in prokaryotic hosts by their inherent complex repeat structure, often leading to truncated versions co-existing with a dwindling population of original length molecules. Recent advances have made it possible to dependably maintain the ITR length in the plasmid transfer vector and thus give rise to better performing AAV vectors containing full, wild-type length ITRs.\u003C/p>\u003Cp>Visitors to this symposium are expected to benefit from a confluence of ideas and people surrounding the AAV vector manufacturing space, including both academia and industry. With all eyes on vector manufacturers to match up and deliver the promise of affordable gene therapy, this event placed rightfully during the ESGCT Annual Congress is expected to provoke new ideas and inspire critical thinking on these lines that will shape the next round of AAV vector manufacturing advances.\u003C/p>\u003Cp>Chairs:\u003Cbr>\u003Cstrong>Dr. Eduard Ayuso, DINAMIQS\u003C/strong>, Schlieren, Switzerland\u003Cbr>\u003Cstrong>Dr. Marco Schmeer, PlasmidFactory GmbH\u003C/strong>, Bielefeld, Germany\u003C/p>\u003Cp>Programme:\u003Cbr>\u003Cstrong>Dr. Marco Schmeer\u003C/strong>, Head of Project Management, PlasmidFactory GmbH, Germany\u003Cbr>\u003Cem> Welcome address\u003C/em>\u003C/p>\u003Cp>\u003Cstrong>Prof. Dr. Hildegard Büning\u003C/strong>, MHH, Hannover, Germany\u003Cbr>\u003Cem> \u0007Improving the quality of AAV vector preparations by exchanging plasmids by minicircles\u003C/em>\u003C/p>\u003Cp>\u003Cstrong>Dr. Michele Gentile\u003C/strong>, ReiThera srl, Rome, Italy\u003Cbr>\u003Cem> Optimization of the Two-Plasmid System for AAV Production\u003C/em>\u003C/p>\u003Cp>\u003Cstrong>Prof. Dr. Kristian Müller\u003C/strong>, Bielefeld University, Germany\u003Cbr>\u003Cem> A Hitchhiker‘s Guide to ITR Stability\u003C/em>\u003C/p>\u003Cp>\u003Cstrong>Dr. Ram Shankar\u003C/strong>, Manager R&D, PlasmidFactory GmbH, Germany\u003Cbr>\u003Cem> ITR maintenance and in-depth analysis for AAV transfer plasmids\u003C/em>\u003C/p>\u003Cp>Questions and discussion\u003C/p>",[],[],{"title":708,"slug":710,"description":712,"start":715,"end":716,"place":717,"subtitle":719,"links":721,"claim":722,"content":724},{"de":6,"en":709},"ESHIMMUNE2024",{"de":6,"en":711},"eshimmune2024-1",{"de":713,"en":714},"Translational Research Conference: Immune & Cellular Therapies: Focus on Advanced Gene-Engineered Immune Cells - triff uns dort","Translational Research Conference: Immune & Cellular Therapies: Focus on Advanced Gene-Engineered Immune Cells - meet us there","2024-09-13","2024-09-15",{"de":6,"en":718},"Malahide (Dublin)/Ireland",{"de":6,"en":720},"ESHaematology – 3rd Translational Research Conference",[],{"de":6,"en":723},"3rd Translational Research Conference: Immune & Cellular Therapies: Focus on Advanced Gene-Engineered Immune Cells",[725],{"headline":726,"subline":728,"description":729,"text":730,"images":731,"files":732},{"de":6,"en":727},"Meet us at our PlasmidFactory Booth",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":6},[],[],{"title":734,"slug":736,"description":738,"start":741,"end":742,"place":743,"subtitle":745,"links":747,"claim":748,"content":749},{"de":735,"en":735},"28th ESACT, 2024",{"de":737,"en":737},"28th-esact-2024",{"de":739,"en":740},"Wir nehmen an dem Meeting der European Society for Animal Cell Technology teil","We take part in the meeting of the European Society for Animal Cell Technology","2024-06-23","2024-06-26",{"de":6,"en":744},"Edinburgh/Scotland",{"de":746,"en":746},"European Society for Animal Cell Technology",[],{"de":6,"en":6},[750],{"headline":751,"subline":752,"description":753,"text":754,"images":756,"files":760},{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":755},"\u003Cp>We will attend this meeting from 23rd –26th June and are exited to meet you there!\u003Cbr>\u003Ca target=\"_blank\" href=\"mailto:contact@plasmidfactory.com\" tt-mode=\"url\">contact@plasmidfactory.com\u003C/a>\u003C/p>",[757],{"url":758,"alt":759},"https://api.plasmidfactory.com/storage/63/responsive-images/ESACT___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"title":762,"slug":765,"description":768,"start":771,"end":772,"place":773,"subtitle":775,"links":777,"claim":778,"content":779},{"de":763,"en":764},"NVGCT, 2024 – Booth follows","NVGCT, 2024 – Annual congress of the Dutch Society of Gene and Cell Therapy",{"de":766,"en":767},"nvgct-2024-booth-follows","nvgct-2024",{"de":769,"en":770},"Wir nehmen an der Jahrestagung der niederländischen Gesellschaft für Gen- und Zelltherapie in Lunteren teil","We will attend the Annual congress of the Dutch Society of Gene and Cell Therapy in Lunteren","2024-06-03","2024-06-04",{"de":6,"en":774},"Lunteren/The Netherlands",{"de":776,"en":6},"Annual congress of the Dutch Society of Gene and Cell Therapy",[],{"de":6,"en":6},[780],{"headline":781,"subline":783,"description":784,"text":785,"images":787,"files":788},{"de":6,"en":782},"– Booth follows –",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":786},"\u003Cp>We will attend this meeting in Lunteren and are exited to meet you there!\u003Cbr>\u003Ca target=\"_blank\" href=\"mailto:contact@plasmidfactory.com\" tt-mode=\"url\">contact@plasmidfactory.com\u003C/a>\u003C/p>",[],[],{"title":790,"slug":793,"description":796,"start":798,"end":799,"place":800,"subtitle":802,"links":804,"claim":805,"content":807},{"de":791,"en":792},"ASGCT, 2024 – Stand 2312","ASGCT, 2024 – 27th Annual Meeting with Tools & Technology lecture",{"de":794,"en":795},"asgct-2024-stand-2312","asgct-2024",{"de":797,"en":797},"Poster at ASGCT: A High Quality Minicircle Production Scale-Up Success Story: AEX-HPLC In-Process Controls to Guide Upstream Process Modification","2024-05-07","2024-05-11",{"de":6,"en":801},"Baltimore/USA",{"de":803,"en":6},"27th Annual Meeting mit Tools & Technology Vortrag",[],{"de":6,"en":806},"See you in Baltimore",[808],{"headline":809,"subline":811,"description":812,"text":813,"images":815,"files":822},{"de":6,"en":810},"Booth 2312",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":814},"\u003Cp>We are delighted to be back at the ASGCT - this year we have another addition to the team! \u003Cbr>Visit us at booth 2312 and find out more about what PlasmidFactory is offering, at our \u003Cstrong>Tools and Technology Forum 4 presentation\u003C/strong>:\u003Cbr>Thursday, May 09 2024 \u003Cbr>04:00 PM – 04:15 PM ET - Exhibit Hall Theater\u003Cbr>\u003Cbr>\u003Cstrong>Posters:\u003C/strong>\u003Cbr>Friday, May 10 2024 \u003Cbr>12:00 PM – 07:00 PM ET - Exhibit Hall\u003C/p>\u003Cp>Poster Number 1518: A High Quality \u003Cem>Minicircle\u003C/em> Production Scale-Up Success Story: AEX-HPLC In-Process Controls to Guide Upstream Process Modification \u003Cbr>Poster  Number 1842: Single-Use Fermenters for Plasmid and Minicircle DNA Production\u003C/p>",[816,819],{"url":817,"alt":818},"https://api.plasmidfactory.com/storage/15/responsive-images/asgct-Baltimore___webp_W___WIDTH____H.webp",{"de":6,"en":6},{"url":820,"alt":821},"https://api.plasmidfactory.com/storage/64/responsive-images/asgct-T%26T-Vortrag-LinkedIn___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"title":824,"slug":826,"description":828,"start":831,"end":832,"place":833,"subtitle":834,"links":837,"claim":838,"content":839},{"de":825,"en":825},"Swiss Biotech Days, 2024",{"de":827,"en":827},"swiss-biotech-days-2024",{"de":829,"en":830},"Triff PlasmidFactory in Basel!","Meet PlasmidFactory in Basel!","2024-04-22","2024-04-23",{"de":6,"en":448},{"de":835,"en":836},"Treffen Sie uns in Basel!","Meet us in Basel!",[],{"de":6,"en":6},[840],{"headline":841,"subline":842,"description":843,"text":844,"images":846,"files":853},{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":845},"\u003Cp>\u003Cstrong>Let’s uncover our opportunities at Swiss Biotech Day 2024!\u003C/strong>\u003Cbr>We will attend this conference from 22nd- 23rd April and are excited to meet you there!\u003Cbr>\u003Ca target=\"_self\" href=\"mailto:contact@plasmidfactory.com\" tt-mode=\"url\">contact@plasmidfactory.com\u003C/a>\u003C/p>",[847,850],{"url":848,"alt":849},"https://api.plasmidfactory.com/storage/65/responsive-images/SwissBiotechDay___webp_W___WIDTH____H.webp",{"de":6,"en":6},{"url":851,"alt":852},"https://api.plasmidfactory.com/storage/66/responsive-images/Basel___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"title":855,"slug":858,"description":860,"start":863,"end":864,"place":865,"subtitle":866,"links":868,"claim":869,"content":871},{"de":856,"en":857},"D.B.T. – German Biotechnology Days","D.B.T. – German Biotechnology Days, 2024",{"de":859,"en":859},"dbt-german-biotechnology-days",{"de":861,"en":862},"Minicircle-gestützte Systeme werden bereits in verschiedenen Anwendungen eingesetzt und haben sich gegenüber Plasmid-DNA als vorteilhaft erwiesen","Minicircle delivery vehicles are already used in diverse applications and proved to be advantageous over conventional plasmid DNA","2024-04-16","2024-04-17",{"de":6,"en":603},{"de":867,"en":6},"untertitel",[],{"de":6,"en":870},"Visit us at the D.B.T. to find out more!",[872],{"headline":873,"subline":875,"description":876,"text":877,"images":879,"files":886},{"de":6,"en":874},"Booth 39",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":878},"\u003Cp>\u003Cstrong>Minicircles: next-generation gene vectors with high potential for clinical applications\u003C/strong>\u003Cbr>The potential of gene therapy in clinical settings relies on the effective delivery of nucleic acids to target cells or tissues. Significant progress has been made in the field using both viral and non-viral vectors as delivery mechanisms. Plasmid DNA remains a crucial starting material for both strategies. Recent regulatory requirements have necessitated the use of safe and advanced Next-Generation Gene Vectors.\u003Cbr>Minicircles are plasmid derivatives engineered to be devoid of bacterial sequence elements, such as antibiotic resistance genes or replication origin. In addition to reducing the size compared to the original plasmid, trimming away these excess sequence enables the molecule to evade host immune responses more effectively and making it better equipped to circumvent gene silencing scenarios post-transfection.\u003C/p>\u003Cp>Minicircle delivery vehicles are already used in diverse applications and proved to be advantageous over conventional plasmid DNA:\u003Cbr>Sleeping Beauty-based transposition is being used to generate CAR-T cells, which are currently considered the most promising tool in cancer therapy. A higher transposition rate was observed when using minicircles compared to plasmids.\u003Cbr>When used for AAV production, minicircles offer unique advantages, eliminating the possibility of backbone sequences being falsely packaged into the transfer vectors.\u003C/p>",[880,883],{"url":881,"alt":882},"https://api.plasmidfactory.com/storage/67/responsive-images/DBT_Logo___webp_W___WIDTH____H.webp",{"de":6,"en":6},{"url":884,"alt":885},"https://api.plasmidfactory.com/storage/68/responsive-images/PHOTO-2024-04-16-14-17-29___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"title":888,"slug":891,"description":893,"start":896,"end":897,"place":898,"subtitle":900,"links":902,"claim":903,"content":905},{"de":889,"en":890},"DG-GT, 2024","DG-GT, 2024 – Annual Meeting",{"de":892,"en":892},"dg-gt-2024",{"de":894,"en":895},"Wir werden persönlich dabei sein, wenn sich Wissenschaftler mit Fragen der experimentellen und klinischen Gentherapie beschäftigen.","We will be there in person when scientists deal with questions of experimental and clinical gene therapy.","2024-03-06","2024-03-08",{"de":6,"en":899},"Munich/Germany",{"de":901,"en":6},"Annual Meeting",[],{"de":6,"en":904},"Meet us in Munich!",[906],{"headline":907,"subline":909,"description":910,"text":911,"images":913,"files":920},{"de":6,"en":908},"30 years DG-GT",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":912},"\u003Cp>We will be there in person when scientists deal with questions of experimental and clinical gene therapy.\u003Cbr>Would you like to meet us there? \u003Cbr>Write us at \u003Ca target=\"_blank\" href=\"mailto:contact@plasmidfactory.com\" tt-mode=\"url\">contact@plasmidfactory.com \u003C/a>to make an appointment!\u003C/p>",[914,917],{"url":915,"alt":916},"https://api.plasmidfactory.com/storage/70/responsive-images/Muenchen-PF-Kopie___webp_W___WIDTH____H.webp",{"de":6,"en":6},{"url":918,"alt":919},"https://api.plasmidfactory.com/storage/69/responsive-images/Mu%CC%88nchen___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"title":922,"slug":925,"description":927,"start":930,"end":931,"place":932,"subtitle":935,"links":937,"claim":938,"content":940},{"de":923,"en":924},"ESGCT, 31th Annual Congress 2024","ESGCT, 2023 – 30th Annual Congress with Lunch Time Symposium",{"de":926,"en":926},"esgct-31th-annual-congress-2024",{"de":928,"en":929},"Minicircles - Vorteile in der Anwendung. Minicircles: Genvektoren der nächsten Generation mit großem Potenzial für klinische Anwendungen","Minicircles – Advantages in application. Minicircles: next-generation gene vectors with high potential for clinical applications","2023-10-24","2023-10-27",{"de":933,"en":934},"Rom/Italien","Brussels/Belgium",{"de":936,"en":6},"Stand und Lunchtime Symposium",[],{"de":6,"en":939},"Minicircles – Advantages in application !",[941,957],{"headline":942,"subline":944,"description":945,"text":946,"images":949,"files":956},{"de":6,"en":943},"Booth 98/99",{"de":6,"en":6},{"de":6,"en":6},{"de":947,"en":948},"\u003Cp>PlasmidFactory wird mit einem Stand vertreten sein und ein Lunchtime-Symposium organisieren!\u003Cbr>\u003Cstrong>Wir sehen uns in Rom!\u003C/strong>\u003C/p>","\u003Cp>\u003Cstrong>Minicircles: next-generation gene vectors with high potential for clinical applications\u003C/strong>\u003Cbr>The promise of gene therapy in the clinic is dependent on the efficient delivery of the corresponding nucleic acids into target cells or tissues. The field has seen some major advances with both viral as well as non-viral vectors as delivery vehicles. Plasmid DNA containing the gene of interest continue to serve as essential starting material for both these strategies. In the past few years, regulatory development has resulted in the need for safe and advanced next generation delivery vehicles. Among many alternatives presented in the field, minicircles offer certain unique advantages and these would be focused upon during this symposium.\u003C/p>\u003Cp>Minicircles are plasmid derivatives engineered to be devoid of bacterial sequence elements such antibiotic resistance genes or replication origin. In this way, they represent a meaningful adaptation of the idea of a gene delivery vehicle – without the problematic and unnecessary sequence elements. Apart from the reduction in size compared to the original plasmid, the trimming away of excess sequence enables the molecule to better evade host immune responses ultimately being better poised to circumvent gene silencing scenarios post-transfection. Moreover, with the removal of the resistance genes, these constructs are a safe bet from a regulatory standpoint going forward to the next generation of gene therapies.\u003C/p>\u003Cp>Thanks to the reduction in size, for example, the amount of DNA required for nucleofecting T-cells can be reduced. Our collaborators used a non-viral sleeping beauty-based transposition to generate CAR-T cells whereby a higher transposition rate was noticed while using minicircles as compared to plasmids. The reduced DNA toxicity experienced by the cells contributed ultimately to a higher yield of CAR-modified T cells. These minicircles were produced in High Quality grade allowing for the GMP production of such CAR-T cells which have actually entered the clinic.\u003C/p>\u003Cp>When used for AAV production, minicircles offer certain unique advantages. The absence of undesired backbone sequences removes the possibility of these sequences being falsely packaged into the transfer vectors. In one of the studies by our collaborators, a head-to-head comparison with the use of plasmids revealed up to a four-fold increase in vector genome yield.\u003C/p>\u003Cp>Furthermore, minicircles are now being used to generate new and better viral vectors based on other systems which will also be showcased in this symposium.\u003C/p>\u003Cp>Finally, PlasmidFactory will touch upon certain unique aspects of these minicircles and elucidate where they stand among the different types of minimal expression cassettes. This would help to bring much needed clarity among gene therapy researchers in this fast-changing landscape.\u003C/p>",[950,953],{"url":951,"alt":952},"https://api.plasmidfactory.com/storage/71/responsive-images/esgct___webp_W___WIDTH____H.webp",{"de":6,"en":6},{"url":954,"alt":955},"https://api.plasmidfactory.com/storage/72/responsive-images/Stand1___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"headline":958,"subline":960,"description":961,"text":962,"images":964,"files":971},{"de":6,"en":959},"Our programm and speakers",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":963},"\u003Cp>\u003Cstrong>An introduction to minicircles\u003C/strong>\u003Cbr>Marco Schmeer, Head of Project Management, PlasmidFactory GmbH\u003C/p>\u003Cp>\u003Cstrong>Invited speakers:\u003C/strong>\u003Cbr>1.     Univ. -Prof. Dr. med. Michael Hudecek, University Hospital, Würzburg, Germany\u003Cbr>\u003Cem>Advanced strategies for gene transfer and gene editing in CAR-T cells\u003C/em>\u003C/p>\u003Cp>2.     Dr. Kathrin Teschner, Sartorius Xell GmbH, Schloss Holte-Stukenbrock, Germany\u003Cbr>\u003Cem>Use of minicircles for the production of AAV in HEK293 cells\u003C/em>\u003C/p>\u003Cp>3.     Dr. Thijs Gerritzen, Amarna Therapeutics, Leiden, The Netherlands.\u003Cbr>\u003Cem>Generation of a new, re-dosable, SV40 viral vector based on minicircle DN\u003C/em>\u003C/p>\u003Cp>\u003Cstrong>Chairs:\u003C/strong>\u003Cbr>1.     Dr. Daniel Scherman, Université Paris Descartes, Paris, France\u003Cbr>2.     Dr. Martin Schleef, PlasmidFactory GmbH, Bielefeld, Germany\u003C/p>",[965,968],{"url":966,"alt":967},"https://api.plasmidfactory.com/storage/73/responsive-images/LunchSymposium-Info___webp_W___WIDTH____H.webp",{"de":6,"en":6},{"url":969,"alt":970},"https://api.plasmidfactory.com/storage/74/responsive-images/Bu%CC%88hne___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"title":973,"slug":976,"description":978,"start":981,"end":982,"place":983,"subtitle":985,"links":987,"claim":988,"content":990},{"de":974,"en":975},"ASGCT, 2023 – Booth 651","ASGCT, 2023 – 26th Annual Meeting with Tools & Technology lecture",{"de":977,"en":977},"asgct-2023",{"de":979,"en":980},"die jüngsten Erfolge von PlasmidFactory bei der Skalierung seiner qualitativ hochwertigen Herstellungsverfahren","focus on PlasmidFactory's recent success in realising the scale-up of its High Quality manufacturing processes","2023-05-16","2023-05-20",{"de":6,"en":984},"Los Angeles/USA",{"de":986,"en":6},"26th Annual Meeting",[],{"de":6,"en":989},"So why not stop by?",[991,1006],{"headline":992,"subline":994,"description":995,"text":996,"images":998,"files":1005},{"de":6,"en":993},"Booth 651 ",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":997},"\u003Cp>\u003Cstrong>Join us for ASGCT’s 26th Annual Meeting!\u003C/strong>\u003Cbr>PlasmidFactory has been regularly showcasing its products and services at this important meeting since many years. This conference is marked by one of the biggest footfalls, over 200 exhibitors, cutting edge science presented in brilliant talks from the top-notch experts in the field and a record number of oral and poster presentations. To put it short: if you were in the cell and gene therapy space, you had to be here!In 2023, we were excited to be back here after a break during the past three years due to the global pandemic and we couldn't wait to meet our customers back in person. In this summer, the meeting moved to the picturesque city of Los Angeles, offering a stunning location for exchanging inspiring ideas and forging new collaborations over dinners at exclusive neighborhoods such as West Hollywood.\u003C/p>\u003Cp>Represented by our Head of Project Management Dr. Marco Schmeer, Quality Management Ms. Mareike Wiedemann and our Manager R&D Dr. Ram Shankar, PlasmidFactory's stand at the Exhibitor Hall was buzzing with activity. Amply supported by our partners from Archimed, our stand was a hub of discussions over the course of four days resulting in multiple new project ideas. We met many familiar faces as well and discussed on how to deepen existing commercial as well as research partnerships. What starts as a friendly chat at the ASGCT booth, goes through countless rounds of emails and video calls over the following months resulting in a potential new study or a viable and productive commercial partnership over the next few years- therefore, the ASGCT annual meeting is an event of paramount importance for us - both scientifically as well as for business. Many thanks to the organisers for putting up such a great show.\u003C/p>",[999,1002],{"url":1000,"alt":1001},"https://api.plasmidfactory.com/storage/75/responsive-images/asgct-logo-altenative___webp_W___WIDTH____H.webp",{"de":6,"en":6},{"url":1003,"alt":1004},"https://api.plasmidfactory.com/storage/76/responsive-images/asgct-Stand___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"headline":1007,"subline":1009,"description":1010,"text":1011,"images":1013,"files":1017},{"de":6,"en":1008},"The Fifteen-minute spotlight - this is your chance!",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":1012},"\u003Cp>\u003Cstrong>26th Annual Meeting with Tools & Technology lecture\u003C/strong>\u003Cbr>An important part of our ASGCT meeting portfolio has always been the exhibitor-exclusive company presentation stage termed Tools and Technology Forum. This fifteen minute-pitch is a major crowd puller at the exhibitor hall and this is where CMOs present their offerings and showcase their expertise in their respective fields. PlasmidFactory has been very successful in the past in these presentations where it is particularly worth mentioning our joint representation with other companies catering to the downstream manufacturing and analytical services for example for AAV vectors. In the 2023 Tools and Technology Forum, PlasmidFactory decided to focus on its recent success in realising the scale-up of its High Quality manufacturing processes. In a detailed presentation, we showed our increase in productivity on the upstream as well as downstream side resulting in the capability for achieving multiple gram quantities of HQ plasmid DNA. We showed how this was possible thanks to the rapid planning and construction of our HQ3 manufacturing facility, thanks to a grant by the state ministry, so that we could accelerate production of HQ plasmid DNA starting material for COVID-19 mRNA vaccine candidates during the pandemic. We also presented a teaser of our next big milestone- following the official announcement of the backing provided by our investors Archimed, work was already started on the construction of our first GMP DNA manufacturing facility, with production expected to roll out in 2024.\u003C/p>\u003Cp>Great surroundings often set the stage for strong partnerships to be founded- in this regard, the closing night reception is an important part of the meeting where unique memories are also made. It's not everyday that you groove to live music with your colleagues and partners while standing beneath an actual space shuttle (Endeavour)!\u003C/p>",[1014],{"url":1015,"alt":1016},"https://api.plasmidfactory.com/storage/77/responsive-images/Ram-ToolsTechnology___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"title":1019,"slug":1022,"description":1024,"start":1027,"end":1028,"place":1029,"subtitle":1031,"links":1032,"claim":1033,"content":1034},{"de":1020,"en":1021},"DG-GT, 2023","DG-GT, 2023 – Annual Meeting",{"de":1023,"en":1023},"dg-gt-2023",{"de":1025,"en":1026},"Grundlagenforschung und angewandte Entwicklung der Gentherapie - weitere Informationen von PlasmidFactory","Basic research and translational development of gene therapy - more information from PlasmidFactory","2023-04-27","2023-04-28",{"de":6,"en":1030},"Langen/Germany",{"de":901,"en":6},[],{"de":6,"en":6},[1035],{"headline":1036,"subline":1038,"description":1039,"text":1040,"images":1042,"files":1049},{"de":6,"en":1037},"Basic research and translational development of gene therapy",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":1041},"\u003Cp>The DG-GT e.V. brings together basic scientists and clinicians who are involved in the most diverse areas of vector development, gene transfer techniques, gene therapy treatment strategies and their implementation in the clinic. We will be there in person and look forward to meeting you and exchanging ideas. Contact via \u003Ca target=\"_blank\" href=\"mailto:info@plasmidfactory.com\" tt-mode=\"url\">info@plasmidfactory.com\u003C/a>\u003C/p>",[1043,1046],{"url":1044,"alt":1045},"https://api.plasmidfactory.com/storage/80/responsive-images/DG-GT___webp_W___WIDTH____H.webp",{"de":6,"en":6},{"url":1047,"alt":1048},"https://api.plasmidfactory.com/storage/81/responsive-images/DG-GT-Adriana-Marco-Kopie___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"title":1051,"slug":1054,"description":1056,"start":1059,"end":1060,"place":1061,"subtitle":1063,"links":1065,"claim":1066,"content":1067},{"de":1052,"en":1053},"D.B.T. German Biotechnology Days 2023","D.B.T. German Biotechnology Days, 2023",{"de":1055,"en":1055},"dbt-german-biotechnology-days-2023",{"de":1057,"en":1058},"Wir sind auf den German Biotechnology Days 2023, DBT","We are at German Biotechnology Days 2023","2023-03-28","2023-03-29",{"de":6,"en":1062},"Wiesbaden/Germany",{"de":1064,"en":6},"Booth 23",[],{"de":6,"en":6},[1068],{"headline":1069,"subline":1070,"description":1071,"text":1072,"images":1074,"files":1081},{"de":6,"en":1064},{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":1073},"\u003Cp>\u003Cstrong>We are in Wiesbaden!\u003C/strong>\u003Cbr>Experience personal contacts, see speakers live, network with familiar and new faces: the Bio Deutschland event is impressive and an innovative, national forum for the German biotechnology industry! \u003Cbr>As companies and scientists, we enjoy the intensive dialogue, new impressions and encounters.\u003C/p>",[1075,1078],{"url":1076,"alt":1077},"https://api.plasmidfactory.com/storage/78/responsive-images/DBT_Logo___webp_W___WIDTH____H.webp",{"de":6,"en":6},{"url":1079,"alt":1080},"https://api.plasmidfactory.com/storage/79/responsive-images/DBT-Standx___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"title":1083,"slug":1085,"description":1087,"start":1090,"end":1091,"place":1092,"subtitle":1094,"links":1095,"claim":1096,"content":1098},{"de":1084,"en":1084},"5th European CAR-T cell Meeting in Rotterdam, 2023",{"de":1086,"en":1086},"5th-european-car-t-cell-meeting-in-rotterdam",{"de":1088,"en":1089},"Mehr über Minicircles für die Produktion von CAR-T-Zellen","More about Minicircles for CAR-T Cell Production","2023-02-09","2023-02-11",{"de":6,"en":1093},"Rotterdam",{"de":1089,"en":6},[],{"de":6,"en":1097},"Meet us here!",[1099],{"headline":1100,"subline":1101,"description":1102,"text":1103,"images":1105,"files":1112},{"de":6,"en":1089},{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":1104},"\u003Cp>\u003Cstrong>We are excited about the broad spectrum of scientific and clinical developments in the field of CAR T and look forward to the latest insights that will be provided by currently reported clinical data.\u003C/strong>\u003Cbr>We also have something to contribute to this promising tool in cancer cell therapy - our own production of an ingenious plasmid - the minicircle! It is not based on viral vectors, but is more accurate, elegant and innovative because it focuses on the GOI (gene of interest).\u003Cbr>The Minicircle has many advantages, not least the decisive factor of its reduced toxicity!\u003Cbr>We are pleased to have the opportunity to discuss this important topic with experts.\u003Cbr>contact@plasmidfactory.com\u003C/p>",[1106,1109],{"url":1107,"alt":1108},"https://api.plasmidfactory.com/storage/82/responsive-images/Bild2-CAR-T___webp_W___WIDTH____H.webp",{"de":6,"en":6},{"url":1110,"alt":1111},"https://api.plasmidfactory.com/storage/83/responsive-images/Bild1-CAR-T___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"title":1114,"slug":1117,"description":1119,"start":1122,"end":1123,"place":1124,"subtitle":1125,"links":1127,"claim":1128,"content":1130},{"de":1115,"en":1116},"ESGCT 2022","ESGCT, 2022 – 29th Annual Meeting",{"de":1118,"en":1118},"esgct-2022",{"de":1120,"en":1121},"PlasmidFactory auf der ESGCT 2022","PlasmidFactory at ESGCT 2022","2022-10-11","2022-10-14",{"de":6,"en":744},{"de":1126,"en":6},"Besuchen Sie uns an Stand 11",[],{"de":6,"en":1129},"Latha math! Will we see you at the ESGCT. Aye?",[1131],{"headline":1132,"subline":1134,"description":1135,"text":1136,"images":1137,"files":1144},{"de":6,"en":1133},"Join us at Booth 11",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":362},[1138,1141],{"url":1139,"alt":1140},"https://api.plasmidfactory.com/storage/84/responsive-images/PlamidFactory-ESGCT-2022___webp_W___WIDTH____H.webp",{"de":6,"en":6},{"url":1142,"alt":1143},"https://api.plasmidfactory.com/storage/85/responsive-images/Edinburgh___webp_W___WIDTH____H.webp",{"de":6,"en":6},[],{"title":1146,"slug":1149,"description":1151,"start":1154,"end":1154,"place":1155,"subtitle":1157,"links":1159,"claim":1164,"content":1165},{"de":1147,"en":1148},"2nd AVP Interactive Workshop on ATMP","2nd AVP Interactive Workshop on ATMP, 2022",{"de":1150,"en":1150},"2nd-avp-interactive-workshop-on-atmp",{"de":1152,"en":1153},"Minicircle DNA als Ausgangsmaterial für die gmp-Herstellung in der CAR-T-Zelltherapie, ATMP","Minicircle DNA as raw material for gmp manufacturing in CAR-T cell therapy, ATMP","2022-09-30",{"de":6,"en":1156},"online, Course No. 6828",{"de":1158,"en":6},"Round table-discussion",[1160],{"title":1161,"target":1163},{"de":6,"en":1162},"Watch the CAR-T cell video","https://www.youtube.com/embed/-wci8TkTeHs",{"de":6,"en":6},[1166],{"headline":1167,"subline":1169,"description":1170,"text":1171,"images":1173,"files":1174},{"de":6,"en":1168},"CAR-T-cells - where do we stand – “Bridging standard pharma concepts and ATMP”",{"de":6,"en":6},{"de":6,"en":6},{"de":6,"en":1172},"\u003Cp>\u003Cstrong>Minicircle DNA as raw material for gmp manufacturing in CAR-T cell therapy\u003C/strong>\u003Cbr>Market supply\u003Cbr>Centralized vs decentralized production\u003Cbr>New developments\u003Cbr>\u003Cbr>\u003Cstrong>Goals of the seminar\u003C/strong>\u003Cbr>The workshop will focus on Advanced Therapy Medical Products (ATMP) as products in development for market supply. Speakers will share background knowledge gained during strategic planning and pharmaceutical development of designated nonorphan drugs. In the afternoon session of the first workshop day round table discussions will provide a platform for the participants to discuss their own topics, issues and strategy in an interactive manner. Share background knowledge for pharmaceutical and strategic development of Advanced Therapy Medical Products (ATMP).\u003C/p>\u003Cp>The workshop will exclusively provide the combination to share background knowledge supportive for market access of ATMP and to discuss questions about own product portfolio.\u003C/p>",[],[],1776471117304]