The better way
to DNA

PlasmidFactory is the leading contract manufacturer and service provider for plasmid DNA and minicircle DNA.

We understand our clients’ needs – PlasmidFactory is an independent and innovative company that offers a combination of flexibility, reliability, and efficiency.

With research and development competence and expertise in a broad range of scientific fields, meticulous attention to plasmid and minicircle DNA production, a high level of quality awareness, and individual customer support from our dedicated scientists, we understand the needs of our customers and deliver tailored solutions quickly.

This is facilitated by a transparent processing procedure, with our PlasmidFactory specialists available for direct communication at all times.

Driven by our passion for nucleic acids and our scientific curiosity, we are ready to take on extraordinary challenges, combining quality and quantity (High Quality grade pDNA in large scale) and delivering the best possible products for our customers.

Products &
Services

Custom DNA

Plasmid DNA
Minicircle DNA

In-Stock DNA

Plasmids & Minicircles for AAV production
Reporter constructs and pEPito plasmids
Molecular Size Markers

Analysis & Storage

CGE Service
Storage Service

PlasmidFactory is not just another plasmid provider.

It is the inventor of a bespoke minicircle technology for AAV and CAR-T cell production, and the only manufacturer that can …

Produce high-purity plasmid and minicircle DNA across a range of quality grades
Generate difficult-to-produce and unstable plasmids and minicircles (e.g. PolyA120, ITRAAV)
Produce up to 10 g of plasmid material per run with low chromosomal DNA impurities
Provide plasmid and minicircle DNA using antibiotic-free fermentation processes
Guarantee a fixed quantity of material, rather than simply selling a production run
Provide AAV 2-Plasmid-System for cotransfection

Get in touch!

Scaling up: We offer DNA products of the highest purity in greater quantities than ever.

Read our large-scale story

Comparison of our quality grades

We provide different quality levels for research and (pre-) clinical studies to ensure optimal adaption to your application. Our High Quality grade* plasmids and minicircles are particularly suitable for GMP-compliant production of viral vectors and RNA, for example.

*HQ: High Quality Grade is produced in accordance with EMA guideline CHMP/BWP/2458/03 as the highest non-GMP quality standard **On request
Grades table as PDF
Research grade
CCC grade basic
CCC grade classic
High Quality grade*
GMP grade
Characteristics
Applications
Applications
Applications
Applications
Applications
Produced by fermentation
Guaranteed amount of plasmid DNA **
Adjustment of DNA concentration included
Customized filling included **
Certified quality incl. QC Report
Storage of glycerol stock and retain samples for repeat orders
Antibiotics-free fermentation
Cultivation media according to EMA/410/01 rev.3, 2011/C 73/01 (TSE/BSE certificate)
All raw materials according to EMA/410/01 rev.3, 2011/C 73/01 (TSE/BSE certificate)
Completely enzyme-free
Characterized and documented cell bank and pilot cultivation
Verified removal of bacterial endotoxins (LPS assay)
Removal of RNA and proteins
Specific removal of bacterial chromosomal DNA and oc-forms
CGE analysis (ccc-supercoiled vs. oc plasmid topologies)
Extended Specification **
Documentation according to GMP/GMP principles
Dedicated lab
QM system applied
Spatially separated upstream and downstream processes
Single use equipment
Compliant with applicable GMP-guidelines and GMP certified

PlasmidFactory offers the combination of flexibility, reliability, and efficiency.

Research & Development

PlasmidFactory produces plasmids and minicircles in modern laboratories according to the requirements of customers worldwide, applying the highest standards and continuously optimized methodologies developed by our own sophisticated R&D department.

About our research & development

We indeed have a very fruitful and productive scientific collaboration with PlasmidFactory for more than 10 years now.

Prof. Dr. Michael Hudecek, Universitätsklinikum Würzburg/2023

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Let us know how
we can help.

Get in touch, that way we can help you in a targeted manner.

I would like personalised advice on the following topic …

  • Manufacturing of customized plasmid DNA
  • Manufacturing of customized minicircle DNA
  • In-Stock products for AAV production
  • In-Stock products (reporter-plasmids/-minicircle)
  • cooperation opportunities
  • Other topic

I would like a specific quote for the following product

  • Customized DNA
  • AAV plasmids und minicircles
  • reporter gene plasmids and minicircles
  • pEPito plasmids
  • Molecular Size Markers
  • CGE Service
  • Storage Service

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We supply customers all over the world

Get information about our ordering and shipping conditions

More about ordering & shipping

Useful background information

The most important terms relating to minicircle DNA and plasmids explained in detail. Useful background information for smooth communication.

We are aware of our responsibility towards our fellow human beings and the environment. We act in accordance with general ESG (Environmental Social Governance) criteria.

ESG