Linearized plasmid & minicircle DNA

Linearized DNA is used as template for mRNA production

PlasmidFactory offers linearisation of plasmid and minicircle DNA as a service, from Research Grade for preclinical research to High Quality grade for mRNA production in GMP quality for clinical studies. GMP-compliant linearisation is also planned.
The development of mRNA vaccines has made significant progress in recent years, particularly in the context of the Sars-CoV-2 pandemic. The production of highly purified plasmid DNA is important in order to avoid impurities that could impair the quality of mRNA. Another key aspect is the usage of linearised plasmid DNA as a starting material for mRNA production, which significantly improves the efficiency and accuracy of vaccine production.

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Plasmids and minicircles are already linearized at PlasmidFactory, thus enabling their immediate use for mRNA production.

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I would like personalised advice on the following topic …

  • Manufacturing of customized plasmid DNA
  • Manufacturing of customized minicircle DNA
  • In-Stock products for AAV production
  • In-Stock products (reporter-plasmids/-minicircle)
  • cooperation opportunities
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I would like a specific quote for the following product

  • Customized DNA
  • AAV plasmids und minicircles
  • reporter gene plasmids and minicircles
  • pEPito plasmids
  • Molecular Size Markers
  • CGE Service
  • Storage Service

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Useful background information

The most important terms relating to minicircle DNA and plasmids explained in detail. Useful background information for smooth communication.

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